What are the short-term impacts of crystal meth on brain chemistry? Each time you get high, crystal floods your brain with serotonin, (your happy “mood” chemical) and dopamine (your “pleasure” chemical). But once the crystal wears off, your serotonin and dopamine levels drop, often below their normal levels. This is why you feel so lousy, and often depressed, during your crash. Given enough time between highs, most brains will “restock” their normal chemical levels naturally. But if you get high again, these levels will surge back up and crash again.
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